@article {Garcia2010a,
	title = {{Analgesic and antiallodynic effects of antidepressants after infiltration into the rat.}},
	journal = {Pharmacology},
	volume = {86},
	number = {4},
	year = {2010},
	month = {jan},
	pages = {216{\textendash}23},
	abstract = {Tricyclic antidepressants (TCA) have potent local anesthetic properties and may produce a long-lasting pain blockade that could be of interest in relieving chronic pain states such as neuropathic pain, but there are only few data comparing their dose-response curves of analgesic activity under the same experimental conditions. This study examines the time course of pain-relieving properties of 7 TCA in heat-induced paw withdrawal after subcutaneous administration. Mixed inhibitors of norepinephrine and serotonin uptake (amitriptyline, nortriptyline, imipramine, desipramine, doxepin) and selective inhibitors of serotonin uptake (fluoxetine and fluvoxamine) were assayed. The TCA with the longest analgesic activity were selected to test its antiallodynic effect in the neuropathic pain model of chronic sciatic nerve constriction injury. Bupivacaine was used as a reference drug in both experiments. A dose versus time of maximal analgesic effect curve was constructed for each drug. The longest analgesic effect was obtained for doxepin and imipramine. Although low doses of amitriptyline showed the same activity than doxepin, higher doses failed to reach the same effect. Selective inhibitors of serotonin showed no action at all doses tested. In the chronic sciatic nerve constriction injury model, doxepin and, to a smaller degree, amitriptyline and imipramine protected from allodynia; bupivacaine was ineffective. The antiallodynic effect always lasted less long than the analgesic effect. These observations provide support for the potential use of TCA as durable analgesics. Doxepin overall showed the most outstanding results in pain relief.},
	keywords = {Adrenergic Uptake Inhibitors, Adrenergic Uptake Inhibitors: administration \& dos, Adrenergic Uptake Inhibitors: pharmacology, Analgesics, Analgesics: administration \& dosage, Analgesics: pharmacology, Anesthetics, Animal, Animals, Antidepressive Agents, Bupivacaine, Bupivacaine: pharmacology, Disease Models, Dose-Response Relationship, Drug, Hyperalgesia, Hyperalgesia: drug therapy, Local, Local: pharmacology, Male, Pain, Pain: drug therapy, Rats, Sciatic Neuropathy, Sciatic Neuropathy: drug therapy, Serotonin Uptake Inhibitors, Serotonin Uptake Inhibitors: administration \& dosa, Serotonin Uptake Inhibitors: pharmacology, Sprague-Dawley, Time Factors, Tricyclic, Tricyclic: administration \&, Tricyclic: pharmacology},
	issn = {1423-0313},
	doi = {10.1159/000319747},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-77956380582\&partnerID=tZOtx3y1},
	author = {Garcia, Xavier and del Valle, Jaume and Escribano, Elvira and Domenech, Josep and Queralt, Josep}
}
@article {Jones2009,
	title = {{Area selection for diamonds using magnetotellurics: Examples from southern Africa}},
	journal = {Lithos},
	volume = {112},
	year = {2009},
	month = {nov},
	pages = {83{\textendash}92},
	abstract = {Southern Africa, particularly the Kaapvaal Craton, is one of the world{\textquoteright}s best natural laboratories for studying the lithospheric mantle given the wealth of xenolith and seismic data that exist for it. The Southern African Magnetotelluric Experiment (SAMTEX) was launched to complement these databases and provide further constraints on physical parameters and conditions by obtaining information about electrical conductivity variations laterally and with depth. Initially it was planned to acquire magnetotelluric data on profiles spatially coincident with the Kaapvaal Seismic Experiment, however with the addition of seven more partners to the original four through the course of the experiment, SAMTEX was enlarged from two to four phases of acquisition, and extended to cover much of Botswana and Namibia. The complete SAMTEX dataset now comprises MT data from over 730 distinct locations in an area of over one million square kilometres, making SAMTEX the largest regional-scale MT experiment conducted to date. Preliminary images of electrical resistivity and electrical resistivity anisotropy at 100 km and 200 km, constructed through approximate one-dimensional methods, map resistive regions spatially correlated with the Kaapvaal, Zimbabwe and Angola Cratons, and more conductive regions spatially associated with the neighbouring mobile belts and the Rehoboth Terrane. Known diamondiferous kimberlites occur primarily on the boundaries between the resistive or isotropic regions and conductive or anisotropic regions. Comparisons between the resistivity image maps and seismic velocities from models constructed through surface wave and body wave tomography show spatial correlations between high velocity regions that are resistive, and low velocity regions that are conductive. In particular, the electrical resistivity of the sub-continental lithospheric mantle of the Kaapvaal Craton is determined by its bulk parameters, so is controlled by a bulk matrix property, namely temperature, and to a lesser degree by iron content and composition, and is not controlled by contributions from interconnected conducting minor phases, such as graphite, sulphides, iron oxides, hydrous minerals, etc. This makes quantitative correlations between velocity and resistivity valid, and a robust regression between the two gives an approximate relationship of Vs [m/s] = 0.045 * log(resistivity [ohm m]) + 4.5. {\textcopyright} 2009.},
	keywords = {Cratonic lithosphere, Diamond exploration, Electrical conductivity, Kaapvaal Craton, Sub-continental lithospheric mantle, Zimbabwe Craton},
	issn = {00244937},
	doi = {10.1016/j.lithos.2009.06.011},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-72149117671\&partnerID=tZOtx3y1},
	author = {Jones, Alan G. and Evans, Rob L. and Muller, Mark R. and Hamilton, Mark P. and Miensopust, Marion P. and Garcia, Xavier and Cole, Patrick and Ngwisanyi, Tiyapo and Hutchins, David and Fourie, C.J.S. and Jelsma, Hielke and Evans, Shane and Aravanis, Theo and Pettit, Wayne and Webb, Sue and Wasborg, Jan}
}
@article {Garcia2007,
	title = {{Acoustic response of cemented granular sedimentary rocks: Molecular dynamics modeling}},
	journal = {Physical Review E},
	volume = {75},
	number = {6},
	year = {2007},
	month = {jun},
	pages = {061308},
	abstract = {The effect of cementation processes on the acoustical properties of sands is studied via molecular dynamics simulation methods. We propose numerical methods where the initial uncemented sand is built by simulating the settling process of sediments. Uncemented samples of different porosity are considered by emulating natural mechanical compaction of sediments due to overburden. Cementation is considered through a particle-based model that captures the underlying physics behind the process. In our simulations, we consider samples with different degrees of compaction and cementing materials with distinct elastic properties. The microstructure of cemented sands is taken into account while adding cement at specific locations within the pores, such as grain-to-grain contacts. Results show that the acoustical properties of cemented sands are strongly dependent on the amount of cement, its stiffness relative to the hosting medium, and its location within the pores. Simulation results are in good correspondence with available experimental data and compare favorably with some theoretical predictions for the sound velocity within a range of cement saturation, porosity, and confining pressure. {\textcopyright} 2007 The American Physical Society.},
	issn = {1539-3755},
	doi = {10.1103/PhysRevE.75.061308},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-34547305692\&partnerID=tZOtx3y1},
	author = {Garcia, Xavier and Medina, Ernesto}
}
