@article {Garcia20154261,
	title = {{Structure of the mantle beneath the Alboran Basin from magnetotelluric soundings}},
	journal = {Geochemistry, Geophysics, Geosystems},
	volume = {16},
	number = {12},
	year = {2015},
	pages = {4261{\textendash}4274},
	abstract = {We present results of marine MT acquisition in the Alboran sea that also incorporates previously acquired land MT from southern Spain into our analysis. The marine data show complex MT response functions with strong distortion due to seafloor topography and the coastline, but inclusion of high resolution topography and bathymetry and a seismically defined sediment unit into a 3-D inversion model has allowed us to image the structure in the underlying mantle. The resulting resistivity model is broadly consistent with a geodynamic scenario that includes subduction of an eastward trending plate beneath Gibraltar, which plunges nearly vertically beneath the Alboran. Our model contains three primary features of interest: a resistive body beneath the central Alboran, which extends to a depth of \~{}150 km. At this depth, the mantle resistivity decreases to values of \~{}100 Ohm-m, slightly higher than those seen in typical asthenosphere at the same depth. This transition suggests a change in slab properties with depth, perhaps reflecting a change in the nature of the seafloor subducted in the past. Two conductive features in our model suggest the presence of fluids released by the subducting slab or a small amount of partial melt in the upper mantle (or both). Of these, the one in the center of the Alboran basin, in the uppermost-mantle (20-30 km depth) beneath Neogene volcanics and west of the termination of the Nekkor Fault, is consistent with geochemical models, which infer highly thinned lithosphere and shallow melting in order to explain the petrology of seafloor volcanics. {\textcopyright} 2015. American Geophysical Union. All Rights Reserved.},
	doi = {10.1002/2015GC006100},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84955347580\&partnerID=40\&md5=9ce7a52b6fe74ed86c20613d5230a4db},
	author = {Garcia, X.a and Seill{\'e}, H.b and Elsenbeck, J.c and Evans, R.L.c and Jegen, M.d and H{\"o}lz, S.d and Ledo, J.e and Lovatini, A.f and Marti, A.e and Marcuello, A.e and Queralt, P.e and Ungarelli, C.f and Ranero, C.R.g}
}
@article {Gori2013,
	title = {{Bathymetrical distribution and size structure of cold-water coral populations in the Cap de Creus and Lacaze-Duthiers canyons (northwestern Mediterranean)}},
	journal = {Biogeosciences},
	volume = {10},
	number = {3},
	year = {2013},
	month = {mar},
	pages = {2049{\textendash}2060},
	abstract = {Submarine canyons are known as one of the seafloor morphological features where living cold-water coral (CWC) communities develop in the Mediterranean Sea. We investigated the CWC community of the two westernmost submarine canyons of the Gulf of Lions canyon system: the Cap de Creus Canyon (CCC) and Lacaze-Duthiers Canyon (LDC). Coral associations have been studied through video material recorded by means of a manned submersible and a remotely operated vehicle. Video transects have been conducted and analyzed in order to obtain information on (1) coral bathymetric distribution and density patterns, (2) size structure of coral populations, and (3) coral colony position with respect to the substrate. Madrepora oculata was the most abundant CWC in both canyons, while Lophelia pertusa and Dendrophyllia cornigera mostly occurred as isolated colonies or in small patches. An important exception was detected in a vertical cliff in LDC where a large L. pertusa framework was documented. This is the first record of such an extended L. pertusa framework in the Mediterranean Sea. In both canyons coral populations were dominated by medium and large colonies, but the frequent presence of small-sized colonies also indicate active recruitment. The predominant coral orientation (90{\textdegree} and 135{\textdegree} ) is probably driven by the current regime as well as by the sediment load transported by the current flows. In general, no clear differences were observed in the abundance and in the size structure of the CWC populations between CCC and LDC, despite large differences in particulate matter between canyons. {\textcopyright} Author(s) 2013.},
	issn = {1726-4189},
	doi = {10.5194/bg-10-2049-2013},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84880722043\&partnerID=tZOtx3y1},
	author = {Gori, A. and Orejas, C. and Madurell, T. and Bramanti, L. and Martins, M. and Quintanilla, E. and Marti-Puig, P. and Lo Iacono, C. and Puig, P. and Requena, S. and Greenacre, M. and Gili, J. M.}
}
@article {Miensopust2013,
	title = {{Magnetotelluric 3-D inversion{\textendash}a review of two successful workshops on forward and inversion code testing and comparison}},
	journal = {Geophysical Journal International},
	volume = {193},
	number = {3},
	year = {2013},
	month = {mar},
	pages = {1216{\textendash}1238},
	abstract = {Over the last half decade the need for, and importance of, three-dimensional (3-D) modelling of magnetotelluric (MT) data have increased dramatically and various 3-D forward and inversion codes are in use and some have become commonly available. Comparison of forward responses and inversion results is an important step for code testing and validation prior to {\textquoteright}production{\textquoteright} use. The various codes use different mathematical approximations to the problem (finite differences, finite elements or integral equations), various orientations of the coordinate system, different sign conventions for the time dependence and various inversion strategies. Additionally, the obtained results are dependent on data analysis, selection and correction as well as on the chosen mesh, inversion parameters and regularization adopted, and therefore, a careful and knowledge-based use of the codes is essential. In 2008 and 2011, during two workshops at the Dublin Institute for Advanced Studies over 40 people from academia (scientists and students) and industry from around the world met to discuss 3-D MT inversion. These workshops brought together a mix of code writers as well as code users to assess the current status of 3-D modelling, to compare the results of different codes, and to discuss and think about future improvements and new aims in 3-D modelling. To test the numerical forward solutions, two 3-D models were designed to compare the responses obtained by different codes and/or users. Furthermore, inversion results of these two data sets and two additional data sets obtained from unknown models (secret models) were also compared. In this manuscript the test models and data sets are described (supplementary files are available) and comparisons of the results are shown. Details regarding the used data, forward and inversion parameters as well as computational power are summarized for each case, and the main discussion points of the workshops are reviewed. In general, the responses obtained from the various forward models are comfortingly very similar, and discrepancies are mainly related to the adopted mesh. For the inversions, the results show how the inversion outcome is affected by distortion and the choice of errors, as well as by the completeness of the data set. We hope that these compilations will become useful not only for those that were involved in the workshops, but for the entire MT community and also the broader geoscience community who may be interested in the resolution offered by MT. {\textcopyright} The Authors 2013. Published by Oxford University Press on behalf of The Royal Astronomical Society.},
	keywords = {Geomagnetic induction, Inverse theory, Magnetotelluric, Numerical solutions},
	issn = {0956-540X},
	doi = {10.1093/gji/ggt066},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84879858225\&partnerID=tZOtx3y1},
	author = {Miensopust, M. P. and Queralt, P. and Jones, A. G.}
}
@article {Garcia2011,
	title = {{Tricyclic Antidepressants-loaded Biodegradable PLGA Nanoparticles: In Vitro Characterization and In Vivo Analgesic and Anti-Allodynic Effect}},
	journal = {Current Nanoscience},
	volume = {7},
	number = {3},
	year = {2011},
	month = {jun},
	pages = {345{\textendash}353},
	abstract = {Tricyclic antidepressants (TCAs) have potent local pain blockade properties that could be of interest in relieving chronic pain states as neuropathic pain. The aim of this work was to reach a persistent control of nociceptive and neuropathic pain by means of an in- jectable controlled release system using lower than usual doses of TCAs. To address this issue, amitriptyline, doxepin and imipramine were encapsulated with poly (lactic-co-glycolic) acid (PLGA) as polymer. Nanoparticles were characterized. The in vitro drug release profile and mechanism was evaluated, and the in vivo analgesic and anti-allodynic activity in front of heat-induced nociceptive pain and sciatic nerve chronic constriction injury, respectively, was tested. The mean{\textpm}SD particle size and drug loadings (\%) of the nanoparticles obtained were 420{\textpm}13, 480{\textpm}73 and 373{\textpm}25nm, and 40.46{\textpm}4.11, 31.09{\textpm}3.02 and 32.20{\textpm}3.20\% for amitriptyline, doxepin and imi- pramine, respectively. According to the Korsmeyer-Peppas model, the release mechanism of doxepin was diffusion controlled, while a combination of Fickian diffusion and polymer relaxation/erosion of the PLGA matrix was involved for amitriptyline and imipramine. Af- ter local infiltration of nanoparticles in rats, the antinociceptive and anti-allodynic activity of the encapsulated drugs were long-lasting and higher than that observed from the solutions. Amitriptyline elicited the lower analgesic effect. Doxepin showed the most outstanding results and its encapsulation led to a 62\% and 229\% increase in antinociceptive and anti-allodynic activity, respectively. So, this drug could be considered as a therapeutical alternative in pain relieving treatments.{\textcopyright} 2011 Bentham Science Publishers Ltd.},
	keywords = {Anti-allodynia, Antinociception, In vitro release, Korsmeyer-peppas, Plga nanoparticles, Tricyclic antidepressants},
	issn = {15734137},
	doi = {10.2174/157341311795542336},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-79956288549\&partnerID=tZOtx3y1},
	author = {Garcia, Xavier and Escribano, Elvira and Colom, Helena and Domenech, Josep and Queralt, Josep}
}
@article {Garcia2010a,
	title = {{Analgesic and antiallodynic effects of antidepressants after infiltration into the rat.}},
	journal = {Pharmacology},
	volume = {86},
	number = {4},
	year = {2010},
	month = {jan},
	pages = {216{\textendash}23},
	abstract = {Tricyclic antidepressants (TCA) have potent local anesthetic properties and may produce a long-lasting pain blockade that could be of interest in relieving chronic pain states such as neuropathic pain, but there are only few data comparing their dose-response curves of analgesic activity under the same experimental conditions. This study examines the time course of pain-relieving properties of 7 TCA in heat-induced paw withdrawal after subcutaneous administration. Mixed inhibitors of norepinephrine and serotonin uptake (amitriptyline, nortriptyline, imipramine, desipramine, doxepin) and selective inhibitors of serotonin uptake (fluoxetine and fluvoxamine) were assayed. The TCA with the longest analgesic activity were selected to test its antiallodynic effect in the neuropathic pain model of chronic sciatic nerve constriction injury. Bupivacaine was used as a reference drug in both experiments. A dose versus time of maximal analgesic effect curve was constructed for each drug. The longest analgesic effect was obtained for doxepin and imipramine. Although low doses of amitriptyline showed the same activity than doxepin, higher doses failed to reach the same effect. Selective inhibitors of serotonin showed no action at all doses tested. In the chronic sciatic nerve constriction injury model, doxepin and, to a smaller degree, amitriptyline and imipramine protected from allodynia; bupivacaine was ineffective. The antiallodynic effect always lasted less long than the analgesic effect. These observations provide support for the potential use of TCA as durable analgesics. Doxepin overall showed the most outstanding results in pain relief.},
	keywords = {Adrenergic Uptake Inhibitors, Adrenergic Uptake Inhibitors: administration \& dos, Adrenergic Uptake Inhibitors: pharmacology, Analgesics, Analgesics: administration \& dosage, Analgesics: pharmacology, Anesthetics, Animal, Animals, Antidepressive Agents, Bupivacaine, Bupivacaine: pharmacology, Disease Models, Dose-Response Relationship, Drug, Hyperalgesia, Hyperalgesia: drug therapy, Local, Local: pharmacology, Male, Pain, Pain: drug therapy, Rats, Sciatic Neuropathy, Sciatic Neuropathy: drug therapy, Serotonin Uptake Inhibitors, Serotonin Uptake Inhibitors: administration \& dosa, Serotonin Uptake Inhibitors: pharmacology, Sprague-Dawley, Time Factors, Tricyclic, Tricyclic: administration \&, Tricyclic: pharmacology},
	issn = {1423-0313},
	doi = {10.1159/000319747},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-77956380582\&partnerID=tZOtx3y1},
	author = {Garcia, Xavier and del Valle, Jaume and Escribano, Elvira and Domenech, Josep and Queralt, Josep}
}
@article {Garcia2010,
	title = {{In vitro characterization and in vivo analgesic and anti-allodynic activity of PLGA-bupivacaine nanoparticles}},
	journal = {Journal of Nanoparticle Research},
	volume = {13},
	number = {5},
	year = {2010},
	month = {jun},
	pages = {2213{\textendash}2223},
	abstract = {An injectable controlled release system containing local anesthetics able to provide longlasting analgesia in nociceptive and neuropathic pain could have a marked impact in pain management. In order to address this issue, bupivacaine, a widely used local anesthetic, has been nanoencapsulated using poly(lactic-co-glycolic acid) from an oil-in-water emulsion by the solvent evaporation technique. Nanoparticles were evaluated in vitro studying their drug release mechanism by fitting different model equations, and in vivo by testing its analgesic and anti-allodynic activity in front of heat-induced nociceptive pain and sciatic nerve chronic constriction injury in rats, respectively. The particle size of the PLGA nanoparticles obtained was of 453 {\textpm} 29 nm, the encapsulation efficiency, drug loading, and burst effect at 30 min were 82.10 {\textpm} 0.001, 45.06 {\textpm} 0.001, and 4.6 {\textpm} 0.6\%, respectively. A prolonged release of the drug in comparison to bupivacaine solution was seen. The mean dissolution time (MDT) obtained for nanoparticles was relatively long (9.44 {\textpm} 0.56 h) proving the sustained release process, while the dissolution efficiency (DE) (84.10 {\textpm} 1.01\%) was similar to the maximum percentage of drug released. Korsmeyer- Peppas was the best model that fitted our release data.A non-Fickian mechanism was concluded to be involved in the release of bupivacaine from the nanoparticles, taking into account the value of the diffusional exponent obtained (n = 0.95). After local infiltration in the rat, the antinociceptive and anti-allodynic activity of the nanoencapsulated bupivacaine was longer lasting than that of bupivacaine solution. An increase in the values of the area under the curve (AUC) of the antinociceptive and anti-allodynic effect versus time of 67 and 36\%, respectively, was observed when the drug was encapsulated. {\textcopyright} Springer Science+Business Media B.V. 2010.},
	keywords = {Antiallodynia, Antinociception, Bupivacaine, In vitro release, Korsmeyer-peppas, Modeling and simulation, Nanomedicine, Plga nanoparticles},
	issn = {1388-0764},
	doi = {10.1007/s11051-010-9979-1},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-79956290523\&partnerID=tZOtx3y1},
	author = {Garcia, Xavier and Escribano, Elvira and Domenech, Josep and Queralt, Josep and Freixes, Joan}
}
